表2因果为精神分裂症在白天小睡频率估计孟德尔随机化。缩写:SNP,单核苷酸多态性;IVW方差倒数加权;MR-RAPS,孟德尔随机化健壮剖面调整分数;MR-PRESSO,孟德尔随机化多向性余量和和离群值
曝光 |
结果 |
单核苷酸多态性(n) |
科克伦的问P价值 |
MR-Egger基因多效性测试P价值 |
方法 |
β(95%置信区间) |
P价值 |
|---|---|---|---|---|---|---|---|
精神分裂症 |
白天小睡频率 |
77年 |
4.05 e-40 |
0.21 |
IVW |
0.0095 (0.0012,0.0178) |
2.50 e-02 |
加权中值 |
0.0106 (0.0035,0.0176) |
3.37 e 03 |
|||||
MR-RAPS |
0.0102 (0.0065,0.0138) |
5.88 e-08 |
|||||
MR-PRESSO |
0.0090 (0.0008,0.0172) |
3.18 e-02 |
|||||
径向先生 |
0.0090 (0.0008,0.0172) |
3.18 e-02 |
|||||
精神分裂症(没有异常值) |
白天小睡频率 |
51 |
0.173 |
0.67 |
IVW |
0.0112 (0.0060,0.0163) |
2.04 e-05 |
加权中值 |
0.0114 (0.0043,0.0185) |
1.67 e 03 |
|||||
MR-RAPS |
0.0115 (0.0066,0.0164) |
3.51 e-06 |
|||||
MR-PRESSO |
0.0112 (0.0060,0.0163) |
9.00 e-05 |
|||||
径向先生 |
0.0112 (0.0060,0.0163) |
2.06 e-05 |